2022

The CRISPR Journal⎜October, 2022

Microfluidic Enrichment and Computational Analysis of Rare Sequences from Mixed Genomic Samples for Metagenomic Mining

Naiwen Cui, Guilhem Faure, Ankita Singh, Rhiannon Macrae & Feng Zhang

📄

Nature⎜October, 2022

Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA

Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max Wilkinson, Soumya Kannan, Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira Makarova, Eugene Koonin, Rhiannon Macrae & Feng Zhang

📄

Science⎜August, 2022

Prokaryotic innate immunity through pattern recognition of conserved viral proteins

Linyi Gao, Max Wilkinson, Jonathan Strecker, Kira Makarova, Rhiannon Macrae, Eugene Koonin & Feng Zhang

📄

Nature Communications⎜March, 2022

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity

Julia Joung, Paul Kirchgatterer, Ankita Singh, Jang Cho, Suchita Nety, Rebecca Larson, Rhiannon Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela Maus & Feng Zhang

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2021

Science⎜September, 2021

The widespread IS200/605 transposon family encodes diverse programmable RNA-guided endonucleases

Han Alta-Tran, Soumya Kannan, Esra Demircioglu, Rachel Oshiro, Suchita Nety, Luke McKay, Mensur Dlakić, William Inskeep, Kira Makarova, Rhiannon Macrae, Eugene Koonin & Feng Zhang

📄

Nature Biotechnology ⎜August, 2021

Compact RNA editors with small Cas13 proteins

Soumya Kannan, Han Altae-Tran, Xin Jin, Victoria Madigan, Rachel Oshiro, Kira Makarova, Eugene Koonin & Feng Zhang

📄

Science⎜August, 2021

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

Michael Segel, Blake Lash, Jingwei Song, Alim Ladha, Catie Liu, Xin Jin, Sergei Mekhedov, Rhiannon Macrae, Eugene Koonin & Feng Zhang

📄

Nature Biotechnology⎜June, 2021

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

Kerstin Ludwig, Ricarda Schmithausen, David Li, Max Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara Hochfeld, Eva Beins, Ines Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Jacob Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang & Jonathan Schmid-Burgk

📄

Cell⎜March, 2021

Dual modes of CRISPR-associated transposon homing

Makoto Saito, Alim Ladha, Jonathan Strecker, Guilhem Faure, Edwin Neumann, Han Altae-Tran, Rhiannon Macrae & Feng Zhang

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PNAS⎜March, 2021

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

Min Qiu, Zachary Glass, Jinjin Chen, Mary Haas, Xin Jin, Xuewei Zhao, Xuehui Rui, Zhongfeng Ye, Yamin Li, Feng Zhang & Qiaobing Xu

2020

Science⎜November, 2020

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes

Xin Jin, Sean Simmons, Amy Guo, Ashwin Shetty, Michelle Ko, Lan Nguyen, Vahbiz Jokhi, Elise Robinson, Paul Oyler, Nathan Curry, Giulio Deangeli, Simona Lodato, Joshua Levin, Aviv Regev, Feng Zhang & Paola Arlotta

📄

QRB Discovery⎜October, 2020

Computational Identification of Repeat-Containing Proteins and Systems

Han Altae-Tran, Linyi Gao, Jonathan Strecker, Rhiannon Macrae & Feng Zhang

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New England Journal of Medicine⎜September, 2020

Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing

Julia Joung, Alim Ladha, Makoto Saito, Nam-Gyun Kim, Ann Woolley, Michael Segel, Robert Barretto, Amardeep Ranu, Rhiannon Macrae, Guilhem Faure, Eleonora Ioannidi, Rohan Krajeski, Robert Bruneau, Meei-Li Huang, Xu Yu, Jonathan Li, Bruce Walker, Deborah Hung, Alexander Greninger, Keith Jerome, Jonathan Gootenberg, Omar Abudayyeh & Feng Zhang

📄

Nature Biomedical Engineering⎜August, 2020

Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA

Maturada Patchsung, Krittapas Jantarug, Archiraya Pattama, Kanokpol Aphicho, Surased Suraritdechachai, Piyachat Meesawat, Khomkrit Sappakhaw, Nattawat Leelahakorn, Theerawat Ruenkam, Thanakrit Wongsatit, Niracha Athipanyasilp, Bhumrapee Eiamthong, Benya Lakkanasirorat, Thitima Phoodokmai, Nootaree Niljianskul, Danaya Pakotiprapha, Sittinan Chanarat, Aimorn Homchan, Ruchanok Tinikul, Philaiwarong Kamutira, Kochakorn Phiwkaow, Sahachat Soithongcharoen, Chadaporn Kantiwiriyawanitch, Vinutsada Pongsupasa, Duangthip Trisrivirat, Juthamas Jaroensuk, Thanyaporn Wongnate, Somchart Maenpuen, Pimchai Chaiyen, Sirichai Kamnerdnakta, Jirawat Swangsri, Suebwong Chuthapisith, Yongyut Sirivatanauksorn, Chutikarn Chaimayo, Ruengpung Sutthent, Wannee Kantakamalakul, Julia Joung, Alim Ladha, Xin Jin, Jonathan Gootenberg, Omar Abudayyeh, Feng Zhang, Navin Horthongkham & Chayasith Uttamapinant

📄

Nature Human Behavior⎜August, 2020

Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing

William Allen, Han Altae-Tran, James Briggs, Xin Jin, Glen McGee, Andy Shi, Rumya Raghavan, Mireille Kamariza, Nicole Nova, Albert Pereta, Chris Danford, Amine Kamel, Patrik Gothe, Evrhet Milam, Jean Aurambault, Thorben Primke, Weijie Li, Josh Inkenbrandt, Tuan Huynh, Evan Chen, Christina Lee, Michael Croatto, Helen Bentley, Wendy Lu, Robert Murray, Mark Travassos, Brent Coull, John Openshaw, Casey Greene, Ophir Shalem, Gary King, Ryan Probasco, David Cheng, Ben Silbermann, Feng Zhang & Xihong Lin

📄

Science⎜August, 2020

Diverse enzymatic activities mediate antiviral immunity in prokaryotes

Linyi Gao, Han Altae-Tran, Francisca Böhning, Kira Makarova, Michael Segel, Jonathan Schmid-Burgk, Jeremy Koob, Yuri Wolf, Eugene Koonin & Feng Zhang

📄

PNAS⎜June, 2020

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

Ayal Gussow, Noam Auslander, Guilhem Faure, Yuri Wolf, Feng Zhang & Eugene Koonin

📄

Cell⎜April, 2020

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

Dan Wang, Feng Zhang & Guangping Gao

📄

Molecular Cell⎜March, 2020

Highly Parallel Profiling of Cas9 Variant Specificity

Jonathan Schmid-Burgk, Linyi Gao, David Li, Zachary Gardner, Jonathan Strecker, Blake Lash & Feng Zhang

📄

2019

Molecular Cell⎜December, 2019

Programmable Inhibition and Detection of RNA Viruses Using Cas13

Catherine Freije, Cameron Myhrvold, Chloe Boehm, Aaron Lin, Nicole Welch, Amber Carter, Hayden Metsky, Cynthia Luo, Omar Abudayyeh, Jonathan Gootenberg, Nathan Yozwiak, Feng Zhang & Pardis Sabeti

📄

Keio Journal of Medicine⎜November, 2019

A Survey of Genome Editing Activity for 16 Cas12a Orthologs

Bernd Zetsche, Jonathan Strecker, Omar Abudayyeh, Jonathan Gootenberg, David Scott & Feng Zhang

📄

Cell⎜October, 2019

Optical Pooled Screens in Human Cells

David Feldman, Avtar Singh, Jonathan Schmid-Burgk, Rebecca Carlson, Anja Mezger, Anthony Garrity, Feng Zhang & Paul Blainey

📄

Nature Protocols⎜September, 2019

SHERLOCK: Nucleic acid detection with CRISPR nucleases

Max Kellner, Jeremy Koob, Jonathan Gootenberg, Omar Abudayyeh & Feng Zhang

📄

Science⎜July, 2019

A cytosine deaminase for programmable single-base RNA editing

Omar Abudayyeh, Jonathan Gootenberg, Brian Franklin, Jeremy Koob, Max Kellner, Alim Ladha, Julia Joung, Paul Kirchgatterer, David Cox & Feng Zhang

📄

Cell⎜June, 2019

DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction

Joshua Weinstein, Aviv Regev & Feng Zhang

📄

Science ⎜June, 2019

RNA-guided DNA insertion with CRISPR-associated transposases

Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan Schmid-Burgk, Kira Makarova, Eugene Koonin & Feng Zhang

📄

Quarterly Reviews of Biophysics ⎜June, 2019

Development of CRISPR-Cas systems for genome editing and beyond

Feng Zhang

📄

Cell Reports ⎜March, 2019

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

Ian Slaymaker, Pablo Mesa, Max Kellner, Soumya Kannan, Edward Brignole, Jeremy Koob, Patricia Feliciano, Stefano Stella, Omar Abudayyeh, Jonathan Gootenberg. Jonathan Strecker, Guillermo Montoya & Feng Zhang

📄

Nature Communications ⎜January, 2019

Engineering of CRISPR-Cas12b for human genome editing

Jonathan Strecker, Sara Jones, Balwina Koopal, Jonathan Schmid-Burgk, Bernd Zetsche, Linyi Gao, Kira Makarova, Eugene Koonin & Feng Zhang

📄

2018

Science ⎜August, 2018

Engineered CRISPR-Cas9 nuclease with expanded targeting space

Hiroshi Nishimasu, Xi Shi, Soh Ishiguro, Linyi Gao, Seiichi Hirano, Sanae Okazaki, Taichi Noda, Omar Abudayyeh, Jonathan Gootenberg, Hideto Mori, Seiya Oura, Benjamin Holmes, Mamoru Tanaka, Motoaki Seki, Hisato Hirano, Hiroyuki Aburatani, Ryuichiro Ishitani, Masahito Ikawa, Nozomu Yachie, Feng Zhang & Osamu Nureki

📄

Science ⎜February, 2018

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Jonathan Gootenberg, Omar Abudayyeh, Max Kellner, Julia Joung, James Collins & Feng Zhang

📄

Nature Biomedical Engineering ⎜April, 2018

Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons

Halil Tekin, Sean Simmons, Beryl Cummings, Linyi Gao, Xian Adiconis, Cynthia Hession, Ayan Ghoshal, Danielle Dionne, Sourav Choudhury, Volkan Yesilyurt, Neville Sanjana, Xi Shi, Congyi Lu, Matthias Heidenreich, Jen Pan, Joshua Levin & Feng Zhang

📄

2017

Science ⎜October, 2017

RNA editing with CRISPR-Cas13

David Cox, Jonathan Gootenberg, Omar Abudayyeh, Brian Franklin, Max Kellner, Julia Joung & Feng Zhang

📄

Nature ⎜October, 2017

RNA Targeting with CRISPR-Cas13

Omar Abudayyeh, Jonathan S. Gootenberg, Patrick Essletzbichler, Shuo Han, Julia Joung, Joseph Belanto, Vanessa Verdine, David Cox, Max Kellner, Aviv Regev, Eric Lander, Daniel Voytas, Alice Ting & Feng Zhang

📄

Nature Methods ⎜August 2017

Massively parallel single-nucleus RNA-seq with DroNc-seq

Naomi Habib, Inbal Avraham-Davidi, Anindita Basu, Tyler Burks, Karthik Shekhar, Matan Hofree, Sourav Choudhury, François Aguet, Ellen Gelfand, Kristin Ardlie, David Weitz, Orit Rozenblatt-Rosen, Feng Zhang & Aviv Regev

📄

Nature ⎜August 2017

Identification of essential genes for cancer immunotherapy

Shashank Patel, Neville Sanjana, Rigel Kishton, Arash Eidizadeh, Suman Vodnala, Maggie Cam, Jared Gartner, Li Jia, Seth Steinberg, Tori Yamamoto, Anand Merchant, Gautam Mehta, Anna Chichura, Ophir Shalem, Eric Tran, Robert Eil, Madhusudhanan Sukumar, Eva Perez Guijarro, Chi-Ping Day, Paul Robbins, Steve Feldman, Glenn Merlino, Feng Zhang & Nicholas Restifo

📄

Molecular Cell ⎜August, 2017

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1

Takashi Yamano, Bernd Zetsche, Ryuichiro Ishitani, Feng Zhang, Hiroshi Nishimasu & Osamu Nureki

📄

Nature ⎜August, 2017

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Julia Joung, Jesse Engreitz, Silvana Konermann, Omar Abudayyeh, Vanessa Verdine, Francois Aguet, Jonathan Gootenberg, Neville Sanjana, Jason Wright, Charles Fulco, Yuen-Yi Tseng, Charles Yoon, Jesse Boehm, Eric Lander & Feng Zhang

📄

Nature Medicine ⎜July, 2017

Implications of human genetic variation in CRISPR-based therapeutic genome

David Scott & Feng Zhang

📄

Nature Biotechnology ⎜June, 2017

Engineered Cpf1 variants with altered PAM specificities

Linyi Gao, David Cox, Winston Yan, John Manteiga, Martin Schneider, Takashi Yamano, Hiroshi Nishimasu, Osamu Nureki, Nicola Crosetto & Feng Zhang

📄

Molecular Cell ⎜June, 2017

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1

Hiroshi Nishimasu, Takashi Yamano, Linyi Gao, Feng Zhang, Ryuichiro Ishitani & Osamu Nureki

📄

Nature Communications ⎜May, 2017

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

Winston Yan, Reza Mirzazadeh, Silvano Garnerone, David Scott, Martin Schneider, Tomasz Kallas, Joaquin Custodio, Erik Wernersson, Yinqing Li, Linyi Gao, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko & Nicola Crosetto

📄

Science⎜April, 2017

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan Gootenberg, Omar Abudayyeh, Jeong Wook Lee, Patrick Essletzbichler, Aaron Dy, Julia Joung, Vanessa Verdine, Nina Donghia, Nichole Daringer, Catherine Freije, Cameron Myhrvold, Roby Bhattacharyya, Jonathan Livny, Aviv Regev, Eugene Koonin, Deborah Hung, Pardis Sabeti, James Collins & Feng Zhang

📄

Cell Reports ⎜April, 2017

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Randall Platt, Yang Zhou, Ian Slaymaker, Ashwin Shetty, Niels Weisbach, Jin-Ah Kim, Jitendra Sharma, Mitul Desai, Sabina Sood, Hannah Kempton, Gerald Crabtree, Guoping Feng & Feng Zhang

📄

Nature Protocols⎜March, 2017

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Julia Joung, Silvana Konermann, Jonathan Gootenberg, Omar Abudayyeh, Randall Platt, Mark Brigham, Neville Sanjana & Feng Zhang

📄

Molecular Cell ⎜March, 2017

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems

Mari Yamada, Yuto Watanabe, Jonathan Gootenberg, Hisato Hirano, F. Ann Ran, Takanori Nakane, Ryuichiro Ishitani, Feng Zhang, Hiroshi Nishimasu & Osamu Nureki

📄

Nature ⎜March, 2017

Transcription control by the ENL YEATS domain in acute leukaemia

Michael Erb, Thomas Scott, Bin E. Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin Roberts, Shiva Dastjerdi, Dennis Buckley, Neville Sanjana, Ophir Shalem, Behnam Nabet, Rhamy Zeid, Nana Offei-Addo, Sirano Dhe-Paganon, Feng Zhang, Stuart Orkin, Georg Winter & James Bradner

📄

Molecular Cell ⎜January, 2017

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

Aaron Smargon, David Cox, Neena Pyzocha, Kaijie Zheng, Ian Slaymaker, Jonathan Gootenberg, Omar Abudayyeh, Patrick Essletzbichler, Sergey Shmakov, Kira Makarova, Eugene Koonin & Feng Zhang

📄

2016

Nature Biotechnology ⎜December, 2016

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, Iana Fedorova, Jeroen Kneppers, Ellen DeGennaro, Nerges Winblad, Sourav Choudhury, Omar Abudayyeh, Jonathan Gootenberg, Wen Wu, David Scott, Konstantin Severinov, John van der Oost & Feng Zhang

📄

Nature Communications ⎜November, 2016

Engineering and optimising deaminase fusions for genome editing

Luhan Yang, Adrian Briggs, Wei Leong Chew, Prashant Mali, Marc Guell, John Aach, Daniel Bryan Goodman, David Cox, Yinan Kan, Emal Lesha, Venkataramanan Soundararajan, Feng Zhang & George Church

📄

Nature Chemical Biology⎜October, 2016

Multidimensional chemical control of CRISPR-Cas9

Basudeb Maji, Christopher Moore, Bernd Zetsche, Sara Volz, Feng Zhang, Matthew Shoulders & Amit Choudhary

📄

Science ⎜September, 2016

High-resolution interrogation of functional elements in the noncoding genome

Neville Sanjana, Jason Wright, Kaijie Zheng, Ophir Shalem, Pierre Fontanillas, Julia Joung, Christine Cheng, Aviv Regev & Feng Zhang

📄

Journal of Biological Chemistry ⎜July, 2016

The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells

Yajian Duan, Gaoen Ma, Xionggao Huang, Patricia D’Amore, Feng Zhang & Hetian Lei

📄

Science ⎜July, 2016

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

Naomi Habib, Yinqing Li, Matthias Heidenreich, Lukasz Swiech, Inbal Avraham-Davidi, John Trombetta, Cynthia Hession, Feng Zhang & Aviv Regev

📄

Science ⎜June, 2016

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR

Omar Abudayyeh, Jonathan Gootenberg, Silvana Konermann, Julia Joung, Ian Slaymaker, David Cox, Sergey Shmakov, Kira Makarova, Ekaterina Semenova, Leonid Minakhin, Konstantin Severinov, Aviv Regev, Eric Lander, Eugene Koonin & Feng Zhang

📄

Scientific Reports ⎜May, 2016

An RNA-aptamer-based two-color CRISPR labeling system

Siyuan Wang, Jun-Han Su, Feng Zhang & Xiaowei Zhuang

📄

Cell ⎜April, 2016

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Hisato Hirano, Ian Slaymaker, Yinqing Li, Iana Fedorova, Takanori Nakane, Kira Makarova, Eugene Koonin, Ryuichiro Ishitani, Feng Zhang & Osamu Nureki

📄

Science ⎜February, 2016

Hypoxia as a therapy for mitochondrial disease

Isha Jain, Luca Zazzeron, Rahul Goli, Kristen Alexa, Stephanie Schatzman-Bone, Harveen Dhillon, Olga Goldberger, Jun Peng, Ophir Shalem, Neville Sanjana, Feng Zhang, Wolfram Goessling, Warren Zapol & Vamsi Mootha

📄

Cell⎜February, 2016

Structure and Engineering of Francisella novicida Cas9

Hisato Hirano, Jonathan Gootenberg, Takuro Horii, Omar Abudayyeh, Mika Kimura, Patrick Hsu, Takanori Nakane, Ryuichiro Ishitani, Izuho Hatada, Feng Zhang, Hiroshi Nishimasu & Osamu Nureki

📄

2015

Science⎜December, 2015

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Christopher Nelson, Chady Hakim, David Ousterout, Pratiksha Thakore, Eirik Moreb, Ruth Castellanos Rivera, Sarina Madhavan, Xiufang Pan, F. Ann Ran, Winston Yan, Aravind Asokan, Feng Zhang, Dongsheng Duan & Charles Gersbach

📄

Science⎜December, 2015

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Mohammadsharif Tabebordbar, Kexian Zhu, Jason Cheng, Wei Leong Chew, Jeffrey Widrick, Winston Yan, Claire Maesner, Elizabeth Wu, Ru Xiao, F. Ann Ran, Le Cong, Feng Zhang, Luk Vandenberghe, George Church & Amy Wagers

📄

Nature Reviews Neuroscience⎜December, 2015

Applications of CRISPR-Cas systems in neuroscience

Matthias Heidenreich & Feng Zhang

📄

Science⎜December, 2015

Rationally engineered Cas9 nucleases with improved specificity

Ian Slaymaker, Linyi Gao, Bernd Zetsche, David Scott, Winston Yan & Feng Zhang

📄

Molecular Cell⎜October, 2015

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

Sergey Shmakov, Omar Abudayyeh, Kira Makarova, Yuri Wolf, Jonathan Gootenberg, Ekaterina Semenova, Leonid Minakhin, Julia Joung, Silvana Konermann, Konstantin Severinov, Feng Zhang & Eugene Koonin

📄

Nature Biotechnology⎜October, 2015

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

James Dahlman, Omar Abudayyeh, Julia Joung, Jonathan Gootenberg, Feng Zhang & Silvana Konermann

📄

Cell⎜September, 2015

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Bernd Zetsche, Jonathan Gootenberg, Omar Abudayyeh, Ian Slaymaker, Kira Makarova, Patrick Essletzbichler, Sara Volz, Julia Joung, John van der Oost, Aviv Regev, Eugene Koonin & Feng Zhang

📄

Nature⎜September, 2015

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Matthew Canver, Elenoe Smith, Falak Sher, Luca Pinello, Neville Sanjana, Ophir Shalem, Diane Chen, Patrick Schupp, Divya Vinjamur, Sara Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart Orkin & Daniel Bauer

📄

Cell⎜August, 2015

Crystal Structure of Staphylococcus aureus Cas9

Hiroshi Nishimasu, Le Cong, Winston Yan, F. Ann Ran, Bernd Zetsche, Yinqing Li, Arisa Kurabayashi, Ryuichiro Ishitani, Feng Zhang & Osamu Nureki

📄

Cell⎜July, 2015

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Oren Parnas, Marko Jovanovic, Thomas Eisenhaure, Rebecca Herbst, Atray Dixit, Chun Jimmie Ye, Dariusz Przybylski, Randall Platt, Itay Tirosh, Neville Sanjana, Ophir Shalem, Rahul Satija, Raktima Raychowdhury, Philipp Mertins, Steven Carr, Feng Zhang, Nir Hacohen & Aviv Regev

📄

Genome Research⎜June, 2015

Sequence determinants of improved CRISPR sgRNA design

Han Xu, Tengfei Xiao, Chen-Hao Chen, Wei Li, Clifford Meyer, Qiu Wu, Di Wu, Le Cong, Feng Zhang, Jun Liu, Myles Brown & X. Shirley Liu

📄

Scientific Reports⎜June, 2015

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

Vyas Ramanan, Amir Shlomai, David Cox, Robert Schwartz, Eleftherios Michailidis, Ankit Bhatta, David Scott, Feng Zhang, Charles Rice & Sangeeta Bhatia

📄

Nature Reviews Genetics⎜April, 2015

High-throughput functional genomics using CRISPR-Cas9

Ophir Shalem, Neville Sanjana & Feng Zhang

📄

Nature⎜April, 2015

In vivo genome editing using Staphylococcus aureus Cas9

F. Ann Ran, Le Cong, Winston Yan, David Scott, Jonathan Gootenberg, Andrea Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira Makarova, Eugene Koonin, Phillip Sharp & Feng Zhang

📄

Cell⎜March, 2015

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Sidi Chen, Neville Sanjana, Kaijie Zheng, Ophir Shalem, Kyungheon Lee, Xi Shi, David Scott, Jun Song, Jen Pan, Ralph Weissleder, Hakho Lee, Feng Zhang & Phillip Sharp

📄

Nature Medicine⎜February, 2015

Therapeutic genome editing: prospects and challenges

David Cox, Randall Platt & Feng Zhang

📄

Nature Biotechnology⎜February, 2015

A split-Cas9 architecture for inducible genome editing and transcription modulation

Bernd Zetsche, Sara Volz & Feng Zhang

📄

2014

Nature⎜December, 2014

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Silvana Konermann, Mark Brigham, Alexandro Trevino, Julia Joung, Omar Abudayyeh, Clea Barcena, Patrick Hsu, Naomi Habib, Jonathan Gootenberg, Hiroshi Nishimasu, Osamu Nureki & Feng Zhang

📄

Nature Biotechnology⎜October, 2014

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

Lukasz Swiech, Matthias Heidenreich, Abhishek Banerjee, Naomi Habib, Yinqing Li, John Trombetta, Mriganka Sur & Feng Zhang

📄

Cell⎜September, 2014

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

Randall Platt, Sidi Chen, Yang Zhou, Michael Yim, Lukasz Swiech, Hannah Kempton, James Dahlman, Oren Parnas, Thomas Eisenhaure, Marko Jovanovic, Daniel Graham, Siddharth Jhunjhunwala, Matthias Heidenreich, Ramnik Xavier, Robert Langer, Daniel Anderson, Nir Hacohen, Aviv Regev, Guoping Feng, Phillip Sharp & Feng Zhang

📄

Nature⎜August, 2014

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Wen Xue, Sidi Chen, Hao Yin, Tuomas Tammela, Thales Papagiannakopoulos, Nikhil Joshi, Wenxin Cai, Gillian Yang, Roderick Bronson, Denise Crowley, Feng Zhang, Daniel Anderson, Phillip Sharp & Tyler Jacks

📄

Nature Methods⎜July, 2014

Improved vectors and genome-wide libraries for CRISPR screening

Neville Sanjana, Ophir Shalem & Feng Zhang

📄

Cell Reports⎜June, 2014

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

Schraga Schwartz, Maxwell Mumbach, Marko Jovanovic, Tim Wang, Karolina Maciag, Guy Bushkin, Philipp Mertins, Dmitry Ter-Ovanesyan, Naomi Habib, Davide Cacchiarelli, Neville Sanjana, Elizaveta Freinkman, Michael Pacold, Rahul Satija, Tarjei Mikkelsen, Nir Hacohen, Feng Zhang, Steven Carr, Eric Lander & Aviv Regev

📄

Cell⎜June, 2014

Development and Applications of CRISPR-Cas9 for Genome Engineering

Patrick Hsu, Eric Lander & Feng Zhang

📄

Genes & Development⎜May, 2014

Global microRNA depletion suppresses tumor angiogenesis

Sidi Chen, Yuan Xue, Xuebing Wu, Cong Le, Arjun Bhutkar, Eric Bell, Feng Zhang, Robert Langer & Phillip Sharp

📄

Nature Biotechnology⎜April, 2014

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Xuebing Wu, David Scott, Andrea Kriz, Anthony Chiu, Patrick Hsu, Daniel Dadon, Albert Cheng, Alexandro Trevino, Silvana Konermann, Sidi Chen, Rudolf Jaenisch, Feng Zhang & Phillip Sharp

📄

Science⎜March, 2014

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

Mark Lee, Chun Ye, Alexandra-Chloé Villani, Towfique Raj, Weibo Li, Thomas Eisenhaure, Selina Imboywa, Portia Chipendo, F. Ann Ran, Kamil Slowikowski, Lucas Ward, Khadir Raddassi, Cristin McCabe, Michelle Lee, Irene Frohlich, David Hafler, Manolis Kellis, Soumya Raychaudhuri, Feng Zhang, Barbara Stranger, Christophe Benoist, Philip De Jager, Aviv Regev & Nir Hacohen

📄

Cell⎜February, 2014

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Hiroshi Nishimasu, F. Ann Ran, Patrick Hsu, Silvana Konermann, Soraya Shehata, Naoshi Dohmae, Ryuichiro Ishitani, Feng Zhang & Osamu Nureki

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